RICTOR and diabetic cardiomyopathy: Using the previously established senolytic regime [38], we subjected STZ mice with dasatinib plus quercetin or vehicle via oral gavage (Seno-STZ-mice versus Veh-STZ-mice) to test if senolytic can reduce EAT senescence and alleviate diabetic cardiomyopathy through inhibition of miRNA-326-3p-Rictor pathway (Fig. 6A).