In addition, some positive signals for anti-CD30 scFv were also observed in the cells localized on the surface of human organs, such as adrenal medulla cells and pancreatic epithelial cells, which was consistent with the previous study that found low expression of CD30 in the pancreas resulted in serious adverse events (pancreatitis) by Brentuximab vedotin treatment37,38. The gene discussed is TNFRSF8; the disease is pancreatitis.