SIRT3 and Shock: In screening septic shock patients from septic patients, we discovered that Sirt3 (AUC = 0.69, 95% CI 0.537 − 0.843, P = 0.031) has better performance than ScvO2 and P(V-A)CO2 (Fig. 3b, Table2), and lactate's specificity in detecting septic shock could be greatly enhanced (from 91.43% to 94.29%) when lactate was utilized in conjunction with Sirt3 (Fig. 3b, Table2).