Mitochondria are the main site for the utilization of oxygen, we discovered that there was a significant difference in ScvO2 between the low Sirt3 and high Sirt3 groups when the factors that influence ScvO2 did not differ statistically, but this result did not appear between the sepsis group and septic shock groups, which implied that Sirt3 had the potential to be an indicator of cellular oxygen utilization in response to septic shock. The gene discussed is SIRT3; the disease is septic shock.