HNRNPC and liver cancer: Moreover, we demonstrate that heterogeneous nuclear ribonucleoprotein C (hnRNPC) physically interacts with primary miR-21 (pri-miR-21) to induce isomiR-21-5p | ±1, highlighting the potential therapeutic value of targeting the hnRNPC-isomiR-21-5p | ±1 regulatory axis in the treatment of liver cancer.