For instance, lncRNA HOTTIP (HOXA transcript at the distal tip) was shown to act as a sponge for the tumor-suppressive microRNA miR-615-3p and dysregulation of HOTTIP expression was shown to alter levels of miR-615-3p and its target IGF-2, promoting the formation of RCC tumors94. This evidence concerns the gene HOTTIP and renal cell carcinoma.