SHBG and cancer: Moreover, a marginally significant inverse genetic correlations were observed between hormone-sensitive cancers and three other non-cancer traits, namely serum oestradiol (rg = −40.86%, se = 8.60%, P = 2.02E-06); calculated free oestradiol (rg = −6.68%, se = 1.60%, P = 3.15E-05); SHBG (rg = −3.33%, se = 1.92%, P = 8.20E-02) and diastolic blood pressure (DBP) (rg = −4.40%, se = 0.02116, P = 3.74E-02) (Fig. 3).