The comparison of tumor volume at 42 days post-tumor inoculation showed that combination group (GE11-Lipo CD73 siRNA+ Lipo Dox) has significant differences compared to PBS, Naked siRNA, Liposomal CD73 siRNA, GE11 liposomal siRNA, and Liposomal doxorubicin groups (P < 0.0001, P < 0.0001, P < 0.0001, P < 0.001, P < 0.001, P < 0.05 respectively). The gene discussed is NT5E; the disease is neoplasm.