MAT2A and hepatocellular carcinoma: However, consistent with our current results, recent study found increased MAT2A, SAM, and other intermediates of methionine cycle, indicating metabolic plasticity in HCC.44–46 Interestingly, it has also been uncovered that the activity and stability of MATIIα proteins are regulated by post-translational modifications including phosphorylation, sumoylation, and acetylation.