However, its expression is decayed to negligible levels after birth and increased in the adult liver upon liver injury and fibrosis.9,39,40 Knocking down MAT2A gene expression causes cell cycle arrest and apoptosis in various cancer cells.41,42 In present study, liver-specific knockout of Mat2a remarkably abolishes HCC development in HFD-induced HCC mouse model. This evidence concerns the gene MAT2A and hepatocellular carcinoma.