Both transcriptional and post-translational mechanisms are uncovered.24 Particularly, acetylating modification accelerates the degradation of MATIIα through ubiquitin-proteasome pathway.7 Although Cullin 3 has been demonstrated as E3 ligase of MATIIα in colorectal cancer cells, deubiquitylase of MATIIα, especially in HCC cells, is rare reported. The gene discussed is CUL3; the disease is hepatocellular carcinoma.