Our previous studies have indicated that folate affected the stability of MATIIα in HCC and CRC cell lines.7,26 We further found that VCIP135 could extend the half-life of MATIIα and rescue the ubiquitylated degradation of MATIIα upon folate deprivation (Fig. 2d, e and Supplementary Fig. S2e). Here, VCPIP1 is linked to hepatocellular carcinoma.