MTOR and arthritic joint disease: It has been well established that the mTORC1 pathway plays an important role in RA progression by regulating synovial hyperplasia, inflammation, and angiogenesis.35,36 Although inhibition of mTOR has a moderate effect on relieving arthritis in RA patients, this strategy cannot completely cure RA.22 Therefore, it is critical to elucidate the roles and mechanisms of specific cytokines regulated by the mTORC1 pathway in RA progression.