This effect was similarly found in bacterial infection-induced inflammation, as ML133 or Kir2.1 deficiency led to a reduction in IL-1β and IL-1α in response to the infection with gram-negative bacteria Escherichia coli and Salmonella typhimurium (strain SL1344) both in vitro (Supplementary Fig. 6A,, B) and in vivo (Fig. 7f). The gene discussed is KCNJ2; the disease is infection.