Using an in vivo LPS-induced sepsis model, we measured decreased serum levels of IL-1β, IL-1α, and IL-6 as well as increased survival of mice treated with ML133 (Fig. 7a–c) or in Lyz2-cre-Kcnj2f/f mice (Fig. 7d, e) compared to controls. The gene discussed is IL1A; the disease is Sepsis.