This effect was similarly found in bacterial infection-induced inflammation, as ML133 or Kir2.1 deficiency led to a reduction in IL-1β and IL-1α in response to the infection with gram-negative bacteria Escherichia coli and Salmonella typhimurium (strain SL1344) both in vitro (Supplementary Fig. 6A,, B) and in vivo (Fig. 7f). This evidence concerns the gene KCNJ2 and bacterial infectious disease.