CD40LG and Sepsis: Giamarellos-Bourboulis et al (2016), using a case–control design, have reported that the study group with a combination of antibiotics plus polyclonal IgM-enriched immunoglobulins (IgM-IG) presented a survival rate higher (61% versus 42%) compared with the comparator group (antibiotics only) until day 28 in patients with sepsis or septic shock caused by multidrug-resistant GNBs, including P. aeruginosa.