The only clinical study evaluating the combination of antibiotics with a single dose of IgM-IG was carried out in patients with sepsis or septic shock by multidrug-resistant GNB infections, in which the group that received antibiotics in combination with IgM-IG had a reduction of the mortality rate compared with the group treated with antibiotics alone (Giamarellos-Bourboulis et al, 2016). Here, CD40LG is linked to Sepsis.