In this regard, a murine pneumonia model in BALB/c mice (Horn et al, 2010) by P. aeruginosa shows that the monoclonal IgM KBPA101 with exclusive reactivity with LPS of serotype O11, administered previously to the bacterial inoculation, reduced the bacterial lungs and spleen concentrations at 48 h. This evidence concerns the gene CD40LG and pneumonia.