To support causality of the MINAR2 mutations in deafness and to begin understanding the mechanism of HL, we show that Minar2tm1b/tm1b mice have a severe, progressive increase in ABR thresholds from 2 wk old onwards (around the time that mice start to hear), with very few responses by 4 wk old. This evidence concerns the gene MINAR2 and Hodgkins lymphoma.