At 10 dpi, the splenic OT-I were a heterogenous population based on KLRG1 and CX3CR1 (Fig 3A) but by 6 weeks post infection, when these cells did not express Nur77-GFP (Fig 2B) there was a more homogeneous (>98%) population of OT-I that maintained a KLRG1+CX3CR1+ phenotype (Fig 7A). The gene discussed is NR4A1; the disease is infection.