Analysis of the CD8+ T cell responses in murine models of acute and chronic toxoplasmosis has highlighted mechanisms that generate and sustain CD8+ T cell responses in the periphery [30,57–59] as well as the presence of a sub-population of Trm-like cell populations in the CNS [12,34,57] that are mirrored in other infections [13,60]. Here, CD8A is linked to infection.