Consistent with the pattern of circulating factors, by 28 days, when the WT lungs were laden with metastases, the burden of cytokines, chemokines, and growth factors was much greater in WT lungs relative to their normal lung controls, while the relative profile from CLIC4-deficient metastasis-free lungs had changed little from the day 14 pattern in tumor-bearing mice, with the exception of ANGPT2 and VEGFR2. The gene discussed is KDR; the disease is neoplasm.