Despite implantation of identical 6DT1 cells, CLIC4 deficiency in the host microenvironment led to relative increases in many factors within the primary tumor proteome, including pro-inflammatory cytokines such as CCL3, also known as macrophage inflammatory protein 1-alpha, at both 14 and 28 days (Fig 6B). The gene discussed is CLIC4; the disease is neoplasm.