In this regard, a recent pan-cancer study aimed at to identify associations between POT1 mutation frequency and tumor type, found that 1834 tumors out of a total of 62,368 tumors harbored a non-benign mutation in POT1 (2.94%) of which angiosarcomas turned out to be 11 times more likely to carry a POT1 mutation than other cancer types [22]. Here, POT1 is linked to angiosarcoma.