HTT and Huntington disease: The mutation of dynein weaken the clearance of mutant huntingtin fragments by cross the HdhHD mice (mouse model of Huntington disease [62]) with Dnchc1Loa (ethylnitrosourea-induced missense mutation in the dynein heavy chain 1[63]), and the level of LC3- II expression in Hdh+/+ Dnchc1Loa/+ mice was increased [35].