Upon viral infection, MITA protected the cells and reduced the viral titer 188-fold (from 106.7 to 104.425 TCID50/ml at 48 h post-infection), whereas Cyp19a1a interfered with the antiviral function of MITA in terms of both CPE and viral titers (from 104.425 to 105.45 TCID50/ml at 48 h post-infection) (Fig 8A and 8B). This evidence concerns the gene STING1 and viral infectious disease.