Mechanistically, accumulation of sequestosome 1 (SQSTM1/p62) in autophagy-deficient hepatocytes leads to the activation of the nuclear factor-erythroid 2-related factor 2 (NRF2) signaling, a central pathway regulating the redox and stress response genes [44], by derepressing NRF2 from Keap1-mediated regulation, thereby promoting adenoma development [29, 45–47]. This evidence concerns the gene NFE2L2 and adenoma.