MAPT and Alzheimer disease: The buildup of abnormally folded protein fragments, including amyloid-beta (Aβ) and tau proteins, which form amyloid plaques (Aβ plaques) and neurofibrillary tangles (NFTs), consecutively, characterizes Alzheimer's disease (AD) dementia (Pluta et al. 2013; Singh et al. 2013).