Interestingly, in vitro essays have revealed that activation of the RAGE/multiligand axis also significantly increases the metastatic potential of breast cancer cells, throughout activation of the RAGE/TLR4/MyD88/NF-kB signaling pathway, which results in elevated expression of MMP9, thus contributing to cancer migration and invasion by degrading ECM in patients with breast cancer [58]. Here, TLR4 is linked to breast carcinoma.