HMGB1 and its subsequent binding to RAGE can trigger the production of proinflammatory cytokines through NF-kB activation [39–42], as well as the expression of pro-invasive and proteolytic matrix metalloproteinases (MMPs), such as MMP2 and MMP9, leading to tumor invasion and metastasis [43]. The gene discussed is HMGB1; the disease is neoplasm.