RAGE activation by members of the calgranulins family (S100A8 and S100A9) contributes to the recruitment and retention of myeloid suppressor cells, as well as increasing the expression of both the alarmins, S100A8/A9, and the activity of inducible nitric oxide synthase and arginase-1, and thus favors tumor growth and metastasis [222–224]. The gene discussed is AGER; the disease is neoplasm.