,103 In the current study, increased MMP-9 expression, particularly in the conjunctiva of NOD.H-2h4 DKO mice that exhibit severe DED (Fig. 2D), correlates with multiple hallmarks of DED in these mice, including reduced tear production (Fig. 4), increased dacryoadenitis (Fig. 3), corneal surface damage (Fig. 1), and increased proinflammatory cytokine expression (Fig. 6). The gene discussed is MMP9; the disease is dacryoadenitis.