,33–35 Recently, researchers in our group determined that deletion of IFNγ and CD28 in NOD.H-2h4 mice (NOD.H-2h4 DKO) leads to much earlier onset of autoimmune thyroiditis36 and SS-like salivary gland disease,28,36–39 with severe phenotypes of these pathologies apparent by four months of age. The gene discussed is CD28; the disease is synovial sarcoma.