We studied expression profiles of molecules like phosphorylated-IRE1-α (p-IRE1-α), total-IRE1-α phosphorylated-PERK (p-PERK), total-PERK, ATF-4, CHOP and phosphorylated-JNK (p-JNK), total-JNK upon infection by JEV and WNV of Neuro-2A (Fig. 4A and 4C) and SH-SY5Y cells (Fig. 4B, S5F). This evidence concerns the gene ATF4 and infection.