PVALB and depressive symptom measurement: Given that (1) anxiety/depression rating is positively correlate with neural activities in sensory processing regions41; (2) reduced gray matter density in bilateral primary somatosensory cortex is found in anxiety patients42; (3) there is a significant decrease parvalbumin‐containing gamma‐aminobutyric acid‐ergic interneurons in somatosensory cortex in deaf mice,40 it is reasonable to assume that the decreased FC between ACC and S1 is convincing.