IGFBP-1 was inversely associated with overall prostate cancer (0.95: 0.91, 0.99; P = 0.03), and IGFBP-2 was not associated with prostate cancer risk (0.98: 0.93, 1.03; P = 0.46) (Figure 1). The gene discussed is IGFBP2; the disease is Familial prostate cancer.