IGF1 and aggressive behavior: In MR analyses, higher IGF-I was associated with increased risks of overall and aggressive disease (OR per genetically predicted 1-SD increment = 1.07: 1.00, 1.15; P = 0.05; and 1.10: 1.01, 1.20; P = 0.04, respectively) and was positively related to risk of early-onset disease (1.13: 0.98, 1.30; P = 0.08) (Figure 1).