CD4 and nonpapillary renal cell carcinoma: We found that the expression of TRIB3 was positively correlated with the expression of immunostimulator and abundance of TILs in ccRCC (Figure 5(j,k)), and was significantly correlated with the abundance of activated CD4+ T cells (r = 0.283, Figure 5(a)), CD56dim natural killer cells (r = 0.274, Figure 5(b)), central memory CD4+ T cells (r = 0.28, Figure 5(c)), and central memory CD8+ T cells (r = 0.405, Figure 5(d)), as well as with increased expression of CD276 (r = 0.339, Figure 5e), IL-6 (r = 0.464, figure 5(f)), TNFRSF18 (r = 0.326, Figure 5(g)), and TNFSF9 (r = 0.315, Figure 5(h)).