Although functional assays were conducted to determine the pathological manifestations of GDM, including the dysregulated glucose transport and insulin sensitivity, the efforts made to deeply investigate the potential factors or precise molecular pathways that may facilitate the deteriorated and/or ameliorated processes were lacking in present study, e.g., how GLUT4 acts in the regulation of glucose metabolism and whether the severity of GDM is associated with the expression level and function of hsa_circ_0046060. The gene discussed is INS; the disease is gestational diabetes.