PLA2G7 and endothelial dysfunction: Besides, 70% of Lp-PLA2 hydrolysed and oxidatively modified low-density lipoprotein (ox-LDL) particles produce metabolites such as haemolytic lecithin and oxidised free fatty acids, which cause endothelial dysfunction, necrosis, and apoptosis through an inflammatory chain reaction, leading to atherosclerosis progression and plaque instability [22].