CGRP modulates synaptic input from the parabrachial nucleus to the CeA (Han et al., 2005, 2015; Okutsu et al., 2017; Shinohara et al., 2017) and plays a critical role in synaptic plasticity in the CeA in an arthritis pain model (Han et al., 2005). The gene discussed is CALCA; the disease is Arthritis.