The key novelties in this study are the sex-specific characterizations of CGRP and CGRP1 receptor component expression levels in the CeA at both acute and chronic stages of neuropathic pain, the differential behavioral modulation by CGRP1 signaling in the CeA between males and females at the chronic stage, and the effects of CGRP1 receptor blockade on CeA-CRF neurons in chronic neuropathic pain. Here, CALCA is linked to Pain.