CALCA and arthritic joint disease: Furthermore, the stereotaxic administration of CGRP into the right CeA of awake rats increased emotional responses (audible and ultrasonic vocalizations) to noxious stimuli and induced mechanical hypersensitivity (lowered hindlimb withdrawal thresholds; Han et al., 2010), and CGRP1 receptor blockade in the CeA reduced mechanical hypersensitivity and emotional responses in an acute arthritis pain model (Han et al., 2005).