The important regulatory role of Notch signaling in this disease was reported in a recent study in which midkine was found to be positively associated with sepsis-induced lung injury in peripheral blood samples from patients with sepsis and in vitro studies showed that Notch 2 was involved in midkine-induced activation of the ACE system and the release of angiotensin II, which in turn led to vascular endothelial lesions [90]. Here, ACE is linked to Sepsis.