Moreover, the mRNA expression levels of C1R, CCL2, and TNFRSF1A in glioblastoma cells or in GBM patients were found to be strongly upregulated (Figure 6 and Supplementary Figure S1), and the mRNA expression levels of these three genes were positively associated with each other (Supplementary Figure S2). This evidence concerns the gene CCL2 and glioblastoma.