In detail, COL1A2, COL1A1, and COL10A1 were enriched in protein digestion and absorption; COL1A2, COL1A1, and SPP1 were enriched in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway; COL1A2 and COL1A1 were further enriched in amoebiasis (Figure 5 and Table 4, P < 0.05). Here, SPP1 is linked to amebiasis.