COL8A1 and cancer: Third, DEGs PPI network complex of 44 nodes and 75 edges was constructed via Cytoscape software and prime module analysis identified 7 hub genes (ADAMTS2, COL10A1, COL1A1, COL1A2, COL8A1, BGN, and SPP1), which were all upregulated genes and were significantly enriched in several cancer-related pathways.