After adjusting for age, TG, TC, LDL-C and HDL-C, Scr, AST, ALT, ALB, APOA1, APOB, and PAB, SUA remained significantly correlated with paroxysmal AF (OR = 1.161, 95% CI 1.039–1.298, P = 0.008). The gene discussed is APOA1; the disease is Paroxysmal atrial fibrillation.