First, it has been demonstrated that ApoA1 levels of paroxysmal AF patients decreased significantly39; Second, the anti-inflammatory and antioxidant properties of HDL-C and APOA1 may prevent the formation of the AF matrix and risk factors40–42; Third, it more and more appeared that abnormal levels of LDL-C might increase the risk of incident AF43,44; In addition, lower serum PAB are associated with inflammatory status, impaired cardiac function, and cardiovascular risk 45,46, and it has been found in the AF patients47. Here, APOA1 is linked to Paroxysmal atrial fibrillation.