Unexpectedly, we found decreased adipogenesis for ASCs in lymphedema, as evidenced by the significantly decreased expression of PPARG and CEBPA (Supplementary Fig. S12a, b), the master regulators in adipogenesis10 as well as significantly decreased adipogenesis score (P value < 2.2e−16, Wilcoxon rank-sum test; Supplementary Fig. S12c). Here, CEBPA is linked to lymphedema.