TREM1 and lymphedema: Given the experimental difficulties of transplantation of LYVE+ macrophages, we tried to increase the ratio of M2/M1 macrophages (0.76 in CASE versus 2.03 in CTRL estimated by us) by inhibiting the pro-inflammatory M1 macrophages that highly expressed TREM1. We proved that the pharmacological blockage of Trem1 using mLR12 could significantly alleviate the lymphedema in a mouse tail model (Fig. 6).