In our study, we did not find any LoF variant in those 13 genes, but we have detected seven likely pathogenic variants in other genes directly related to immune response (IFN pathways, mainly).We have confirmed the presence of a TLR7 variant in a male also participating in a recently published study16, suffering from very severe COVID-19 and without relevant comorbidities or risk factors at the time of the infection. Here, IFNA1 is linked to infection.