CD8A and neoplasm: Similarly, in the presence of ATG5 and ATG7, as a result of endocytosis and autophagic degradation of the MHCI complex in DCs, antigen presentation and CD8+ T cells priming are inhibited, which is reversed in DCs with absence of autophagy.287 Recently, one study shows that radiotherapy-induced autophagy increases CD8+ T cells infiltration by modulating MHCI expression in NSCLC, but the direct relationship of MCHI expression with autophagy is still unclear.288 Likewise, E3 ubiquitin ligase leads to MHCII complex degradation in MDSCs, causing tumor immunity evasion.