GSDMD and neoplasm: A carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer (CA-Re) shows favorable efficacy in photodynamic treatment for effectively stimulating tumor immunogenicity under hypoxic conditions through GSDMD-independent pyroptosis.421 Moreover, the maturation and antigen-presentation capacity of DC cells as well as the activation of CTLs is enhanced by CA-Re, thus killing tumors.