In addition, deletion of MLKL in breast cancer cells reduced lung metastasis.355 In some cancer types, tumor cells have also shown a tendency to induce necroptosis in endothelial cells, causing the transendothelial migration and metastasis of tumor cells via expression of amyloid precursor protein.356 There is some uncertainty whether the effects on metastasis result from necroptosis itself or disruption of endothelial barriers. This evidence concerns the gene APP and neoplasm.