Besides, the autophagy activator adiponectin ADIPOQ and 2-aminonicotinonitrile compound (w09) significantly inhibit breast cancer growth by stimulating autophagy through the serine/threonine kinase 11 (STK11)-AMPK-ULK1 and EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway, respectively.388,389. This evidence concerns the gene MAPK1 and breast carcinoma.