Besides, the release of calreticulin and ATP from colon tumors cells through autophagy activated by radiotherapy promotes phagocytosis of tumor cells by DC cells.444,445 Stereotactic body radiation therapy (SBRT) combined with oncolytic virus enhances antitumor immunity by altering the M1/M2 ratio of macrophages through necroptosis.446 Targeted therapies can also promote ICD and produce immunogenic effects while inhibiting tumor proliferation. This evidence concerns the gene CALR and neoplasm.