In B16-F10 and 4T1 mouse tumor models, autophagy of tumor cells induced by hypoxia degrades NK cell-derived GZMB thereby impairing the tumor lysis function of NK cells.283 Mechanically, hypoxia-inducible factor-2α (HIF-2α) transports into the nucleus and activates the autophagy sensor inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) to degrade GZMB. The gene discussed is ITPR1; the disease is neoplasm.