A recent study has shown that as autophagy receptor for PD-L1 binding, Huntingtin-interacting protein 1-related (HIP1R) induces PD-L1 degradation in lysosomes, subsequently suppressing the tumor growth via activation of T cells.194 However, cancer cells inhibit the degradation of PD-L1 by autophagy via transcriptional modification. This evidence concerns the gene CD274 and cancer.