NBR1 and neoplasm: Besides, tumor cells can evade immune surveillance through autophagy to degrade MHCI complexes.198,285 For example, in pancreatic cancer cells resistant to ICIs, the MHCI complex is re-transported to the lysosome for selective autophagy by ubiquitin-binding receptor NBR1 and degraded, thereby preventing T cells recognition.286 By contrast, inhibition of autophagy restores the level of MHCI complex and improves antigen presentation, enhancing antitumor T cells responses and therefore reducing tumor growth.