In addition, 3-methylcholanthrene (3MCA), a chemical carcinogen, induces the development and invasiveness of tumors if it is exposed to IL-1β.317 Furthemore, chronic inflammation results in the induction of immune-suppressive MDSCs, TAMs, and NK cells mediated by IL-1β.318 To sum up, the key mechanisms of IL-1β-mediated tumor development include infiltration of immunosuppressive cells,319 tumor angiogenesis320, and driving chronic inflammation.312,313. This evidence concerns the gene IL1B and neoplasm.