It has been shown that in human melanoma, expression of the key autophagosomal component LC3-β and other autophagy activators reduces melanoma antigen-A (MAGE-A) protein levels and suppresses the MAGE-Tripartite Motif Containing 28 (TRIM28) complex which predicts resistance uniquely to blockade of CTLA-4, suggesting exploitation of autophagy inducer such as ADIPOQ, w09 for potential therapeutic synergy with CTLA-4 inhibitors.388,389,413. Here, CTLA4 is linked to melanoma.