In the past, perforin has been thought to be the only protein responsible for pore formation on CD8+ T cells,208 but it was suggested by the authors that GSDMD could be a new pore-forming protein utilized by effector T cells to form pores in tumor cells.40 Nevertheless, the mechanism of GSDMD transportation from CD8+ T cells to tumor cells remains to be further explored. This evidence concerns the gene PRF1 and neoplasm.