GSDMD and neoplasm: Then, CASP1 is activated via pyroptosis releasing factor, which cleaves GSDMD in macrophages, causing the release of cytokine and cytokine release syndrome (CRS), a serious side event characterized by fever, hypotension, and respiratory failure.422 Thus, the development of more efficient drugs causing tumor-specific pyrolysis and decreasing pyrolysis in normal tissues is in urgent need.