Multiple of evidence suggests that DAMPs released from cells through necroptosis may also recruit inflammatory cells and release regulatory cytokines such as IL-1α, IL-18, etc. to trigger inflammation and promote tumor development by promoting angiogenesis, cancer cell proliferation, and thus metastasis.4,41,357–359 The role of cytokines and DAMPs such as HMGB1, ATP, etc. has been described in detail in the pyroptosis section of this paper. The gene discussed is HMGB1; the disease is cancer.