Likewise, Zhang et al. designed the engineering covalent organic frameworks (COFs) that could induce durable antitumor immunity through robust induction of GSDME-mediated pyroptosis and the remodeling of TME, thus improving immunotherapy response and restraining tumor metastasis and relapse.421 However, induction of pyroptosis may not benefit all immunotherapies. The gene discussed is GSDME; the disease is neoplasm.