GSDMD and cancer: High GSDMD expression was associated with aggressiveness of NSCLC, including larger tumor volume and higher TNM stage.126 Nevertheless, activation of pyroptosis can also induce potent antitumor activity.127 For example, in hepatocellular carcinoma (HCC) cells, pyroptosis induced by NLRP3 inflammasomes significantly impedes tumor growth characteristics and metastatic potential.128 Aside from the digestive system,129,130 pyroptosis acts an equally important part in the development of cancers in respiratory,131 reproductive,132 and hematopoietic systems.133