Further analysis revealed that the specific effect of IL-18 was associated with high expression of IL-18 gene in gastric cancer epithelial cells, whereas IL-1β was preferentially expressed in immune cells whose knockdown did not inhibit gastric carcinogenesis.292 And IL-18 induces migration of breast cancer cells through downregulation of claudin-12 as well as activation of the p38-MAPK pathway.191 Besides, IL-18 is able to induce angiogenesis which leads to increased migration/invasion in tumors and immune escape.293,294. This evidence concerns the gene MAPK1 and breast cancer.