In addition, inactivating both Sting and ATG7 gene led to the restoration of tumor growth in mice, showing that tumors are inhibited by innate immunity activation via STING by autophagy impairment.256 In addition to type I /II IFN, interestingly, gene expression profiling of tumor models showed that CTLs produced higher levels of IFNγ specifically in autophagy-deficient tumor models. The gene discussed is IFNG; the disease is neoplasm.