The Cox proportional risk model showed that the expression of RIPK3 is an independent prognostic factor in colorectal cancer patients with regards to overall survival and disease-free survival.154 Recently, a study has shown that the expression of RIPK1, RIPK3, and MLKL was linked to better overall survival in HCC.155 Furthermore, methylation near the transcription start site silences RIPK3 expression in cancer cells. This evidence concerns the gene RIPK1 and cancer.