T cells and IFNG are both required to induce tumor rejection by specific deletion of autophagy in liver hepatocytes.256 In order to block selectively autophagy to overcome hepatic autophagy immune tolerance, we need to uncover the exact mechanism by which autophagy loss activates STING-type I/II IFN pathway and IFNG/IFNγ activation in the hepatocytes. This evidence concerns the gene IFNG and neoplasm.