CD8A and cancer: GZMA may be delivered by immune cells to GSDMB-expressing cancer cells to promote antitumor immunity.114 In addition, a previous study showed that GSDMD plays a key role in antitumor function of CD8+ T cells.131 GSDMD and GZMB coexist near immune synapse and GSDMD deficiency has been shown to reduce the cell-killing capacity of CD8+ T cells.