CD274 and Familial prostate cancer: Due to the interaction of SIGMA I with glycosylated PD-L1, IPAG, the SIGMA I inhibitor restored T cells activity in breast/prostate cancer cells by preventing PD-L1 autophagy.452 Furthermore, PD-L1 antibody H1A inhibits PD-L1 interaction with CMTM6, which results in PD-L1 autophagy.453