Zhang et al. reported that CD8+ T cells and NK cells induce pyroptosis of tumor cells independent of caspases through the GSDME-GZMB axis in their study.31 Recent studies have shown CD8+ T cells and NK cells can evoke tumor pyroptosis through the GSDMB-GZMA axis, which is induced by interferon-γ(IFNγ). This evidence concerns the gene CD8A and neoplasm.