GSDME and neoplasm: Similarly, pyroptosis induction alone did not trigger effective tumor suppression, emphasizing the importance of pyroptosis inducers in combination with ICIs for the treatment of cold tumors.29 Lu et al. designed NK92 cells containing a chimeric co-stimulatory transforming receptor (CCCR) that converted inhibitory PD-1 signals into activation signals, effectively enhancing its activity against H1299 lung cancer cells and significantly inhibiting tumor growth in vivo.420 Further analysis concluded that it was achieved through GSDME-mediated pyroptosis.