The presence of RUNX1 mutations was positively correlated with the presence of MR mutations in AML, NOS (chi-square test; p < 0.001): RUNX1 mutations were twice as frequent in the presence of MR mutations compared to their absence (38% vs 19%, MR-mutated vs MR-wild-type AML, NOS). The gene discussed is RUNX1; the disease is acute myeloid leukemia.