This is in concordance with the more established role of TAMs in CLL, where TAMs induce lymphoma survival via secretion of a proliferation-inducing ligand (APRIL), BAFF, CXCL12 and -13, and Wnt5a, and via stimulation of the BCR and CD38 [40, 41]. This evidence concerns the gene TNFSF13B and B-cell chronic lymphocytic leukemia.