Increased miR-486-3p represses cells metastasis and proliferation in many tumors including cervical cancer [34], oral cancer [35] and squamous cell carcinoma [36], suggesting that circ-EPB41 overexpression also suppressed NSCLC cell metastasis and proliferation via adsorption of miR-486-3p. The gene discussed is EPB41; the disease is lip and oral cavity carcinoma.