EPB41 and non-small cell lung carcinoma: These results indicated that downregulation of miR-486-3p or overexpression of eIF5A restored the sphere percentage in H1650 and A549 cells (Fig. 7A–C), suggesting that circ-EPB41 expression enhanced NSCLC progression by regulating miR-486-3p/eIF5A axis-mediated stemness.