Increased miR-486-3p represses cells metastasis and proliferation in many tumors including cervical cancer [34], oral cancer [35] and squamous cell carcinoma [36], suggesting that circ-EPB41 overexpression also suppressed NSCLC cell metastasis and proliferation via adsorption of miR-486-3p. Here, EPB41 is linked to non-small cell lung carcinoma.