By constructing a Boolean model of signaling pathways in CRC and simulating perturbations to every node in the model under an asynchronous updating scheme, Park et al. showed that BRAFi combined with SRC inhibition (SRCi) prevented the development of adaptive resistance via inhibition of ERK (MAPK1), a member of the MAPK signaling pathway. Here, SRC is linked to colorectal carcinoma.