In the clinical trial CTONG 1104 (the 1st generation EGFR-TKI adjuvant gefitinib improves disease-free survival (DFS) for resected EGFR-mutant NSCLC with N1/N2 metastasis), we found that significant TCR rearrangements (Vβ5-6-Jβ2 − 1, Vβ20-1-Jβ2 − 1, Vβ24-1-Jβ2 − 1, and Vβ29-1-Jβ2–7) in NSCLC patients are associated with favorable overall survival (OS) and may have a specific response to tumor gene mutations [27]. The gene discussed is EGFR; the disease is neoplasm.