When ephrinB2 was knocked down on tumor cells and implanted orthotopically, a modest decrease (680.5 mm3 in control to 415.9 mm3 in EphrinB2 sh) in tumor growth was noted only in the Moc2 tumor model, where we have established higher levels of expression on the cancer cells (Fig. 2a and Supplementary Fig. 6a). This evidence concerns the gene EFNB2 and cancer.