To investigate the role of vascular ephrinB2 and its contribution to HNSCC tumor progression, we used a genetically engineered EFNB2fl/flTie2-Cre-ERT mouse model in which Efnb2 is conditionally knocked out from the endothelial vasculature (Supplementary Fig. 5b). The gene discussed is EFNB2; the disease is neoplasm.