EPHB4 and neoplasm: Specifically, shRNA knockdown of EphB4 resulted in a significant increase in median tumor volume in Moc2 (680.5 mm3 in control to 888.7 mm3 in EphB4 sh) and Ly2 tumor-bearing mice (402.5 mm3 in control to 762 mm3 in EphB4 sh), as shown in Fig. 2a, b.