In the MEER tumor model, complete knockout of EphB4 on cancer cells similarly resulted in a significant enhancement (p = 0.0006) in mean tumor volume compared to the control cohort (198.8 mm3 in control to 1024 mm3 in EphB4 KO) (Fig. 2d and Supplementary Fig. 6d). This evidence concerns the gene EPHB4 and neoplasm.