To test this hypothesis, we first examined the expression of ephrinB2 and EphB4 in a compartment-specific manner in different murine (Moc2, Ly2, and MEER) and patient-derived xenograft (CUHN013) HNSCC models, with a particular focus on cancer cells and vascular endothelial cells. This evidence concerns the gene EPHB4 and head and neck squamous cell carcinoma.