In fact, on the one hand, factors that positively correlate with TG2 such as CCL4 and CCL5 chemokines, VEGF-C, and CD40 ligand all contribute to the recruitment of dendritic cells (DCs), which are known to promote cytotoxic CD8 + T-cells infiltration in tumor microenvironment by antigen-cross presentation, enhancing patients’ survival and response to ICIs [44]. This evidence concerns the gene CCL4 and neoplasm.