N-cadherin was reduced when EGFR was blockaded in TNBC cells (Fig. 2H, I and J); otherwise, overexpressed-EGFR upregulated N-cadherin in MDA-MB-453 cells (Fig. 2H), accompanied with enlarged size of tumor spheres (Fig. S3F); ADH-1 (MedChemExpress, Shanghai, China), a N-cadherin antagonist, repressed EGFR-mediated enlarged size of tumor spheres (Fig. S3F). Here, CDH2 is linked to neoplasm.