The use of IBD-iMphs also allowed to identify a novel regulatory loop between deficient IL-10 signaling and prostaglandin E2 overproduction and to demonstrate that the mutation leads not only to macrophage overactivation, but also to a hampered macrophage antibacterial control (as shown using S. typhimurium intracellular infection [71]). The gene discussed is IL10; the disease is inflammatory bowel disease.