iPS-MLs (OP9-dependent) transduced with scFv specific to human HER2/neu antigen along with IFNα, IFNβ, IFN-γ, TNF-α, TRAIL or FAS-ligand genes were generated and their anti-tumor activity was tested in severe combined immunodeficiency (SCID) mice with human gastric and pancreatic cancer. This evidence concerns the gene ERBB2 and neoplasm.