In obese rats, preventing OVX-induced weight gain also decreased adipocyte size and adipose inflammation and reduced expression of the tumor-promoting growth factor FGF-1, which associated with decreased phosphorylation of FGFR1 in mammary tumors, potentially contributing to the anti-tumor effects of the intervention (Summarized in Fig. 5). This evidence concerns the gene FGFR1 and neoplasm.