In oophorectomized rats fed a high-salt diet (HSD), the elevation of MR and the reduction of a subunit of ATP1α3 were associated with augmented brain damage after ischemia [15], and the down-regulation of ATP1α2 and ATP1α3 was associated with epileptic encephalopathy [16]. Here, ATP1A3 is linked to Epileptic encephalopathy.