Compared to the sham/SD rats, the expression levels of RAGE, MR, and HMGB1 in the rats with unruptured and ruptured aneurysms were significantly increased in the brain parenchyma adjacent to the Lt PCA with unruptured and ruptured IAs, but not in other areas (Fig. 2A). The gene discussed is HMGB1; the disease is aneurysm.