In an older population without prevalent cardiovascular disease, we determined whether a wide variety of glucose measures, including fasting glucose, 2-h glucose, homeostatic model of insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI) and insulin secretion, are associated with worse LV systolic strain (LVLS), LV early diastolic strain rate (LVDSR), and LA reservoir strain (LARS), as measured by speckle-tracking echocardiography. Here, INS is linked to cardiovascular disorder.