In univariable analyses, CK19 expression, presence of MVI, BCLC stage B, HBsAg positive, HBV-DNA ≥ 5 × 102 IU/ml, large tumor diameter, tumor number ≥ 2, AFP ≥400 ng/ml, high N%, low L% , low Alb, low PA, high GGT, and high ALP were significantly associated with worse DFS after radical resection. This evidence concerns the gene AFP and neoplasm.