DNMT3A and pulmonary fibrosis: Therefore, we cannot rule out a potential role of DNMT3A and DNMT1 in regulating macrophage polarization during fibrosis, and other studies have already shown that both DNMT1 and DNMT3A play a role in the development of pulmonary fibrosis by modulating DNA methylation in lung fibroblasts and alveolar epithelial cells [18].