GDF15 and Anorexia: In a study conducted by Kuno et al. [11] and Lerner L et al. [15], which included the same model of cachexia, they showed that overproduction of GDF-15 in cancer patients was the main cause of cancer anorexia and cachexia, and it led to the symptoms of chronic nausea and vomiting in HEG.They also found that ADAMTS-1 and GDF-15 together may be associated with cancer cachexia.